S1PR5

Across TCGA cell cohorts, S1PR5 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible S1PR5-associated genes across cancer lineages are SFT2D3, IQCF1, and FOXS1. Each is linked with S1PR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both S1PR5-to-partner and partner-to-S1PR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SFT2D3 grouped by S1PR5-low versus S1PR5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S1PR5→partner) and Y-score (partner→S1PR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SFT2D3 →	+0.543	+3.450	<.001	.004	3	1
BLOOD_Leukemia	IQCF1 →	+0.092	+4.091	<.001	.002	3	1
BLOOD_Leukemia	FOXS1 →	+0.067	+3.551	<.001	.008	3	1
BLOOD_Leukemia	IQCF5 →	+0.061	+4.201	<.001	.001	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SFT2D3 by S1PR5 expression — BLOOD_Leukemia

Explore this box plot interactively →