S1PR4

Across TCGA pan-cancer cohorts, S1PR4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated S1PR4 data layer compared with 27 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher S1PR4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated S1PR4 expression acts as an unfavorable survival marker.

COAD, LGG, and BRCA are the cancer types where S1PR4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	III,IV	0.143	0.703	.002	18	view →
LGG	OS	Median	All	0.217	0.812	<.001	15	view →
BRCA	OS	Median	II,III,IV	0.132	0.565	.015	8	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
HNSC	OS	Median	IV	0.115	0.733	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

S1PR4–COAD (OS)

Open the COAD breakdown →