S1PR4

Across TCGA patient cohorts, S1PR4 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,841 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible S1PR4-associated proteins across cancer lineages are ARHGAP45, ARHGAP9, and ARHGDIB. Each is linked with S1PR4 in more than 9 cancer types. Because this analysis shows association rather than direction, both S1PR4-to-partner and partner-to-S1PR4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, S1PR4 versus ARHGAP45 in GBM, with a Pearson correlation of 0.68.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (S1PR4→partner) and Y-score (partner→S1PR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP45 →	+0.556	+0.656	<.001	<.001	3	10
UCEC	ARHGAP9 →	+0.504	+1.351	<.001	<.001	3	10
COAD	ARHGDIB →	+0.740	+0.823	<.001	<.001	3	10
BRCA	PTPN7 →	+0.650	+1.096	<.001	<.001	3	10
OV	RASAL3 →	+0.564	+0.716	<.001	<.001	3	10
LSCC	RCSD1 →	+0.631	+0.915	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,841 associations by consensus.

S1PR4 vs ARHGAP45 — GBM

Explore this scatter interactively →