S1PR4

Across TCGA patient cohorts, S1PR4 protein abundance is significantly associated with the RNA expression of many other genes, with 1,400 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible S1PR4-associated genes across cancer lineages are TFPT, GMDS, and A4GALT. Each is linked with S1PR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both S1PR4-to-partner and partner-to-S1PR4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, S1PR4 versus TFPT in LUAD, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S1PR4→partner) and Y-score (partner→S1PR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TFPT →	+0.603	+0.414	.003	.003	3	1
LUAD	GMDS →	+0.701	+0.423	<.001	.001	3	1
LUAD	A4GALT →	+1.151	+0.500	<.001	.008	3	1
LUAD	ZNF236 →	+0.357	+0.362	.007	.006	3	1
LUAD	PGBD1 →	+0.547	+0.518	.002	<.001	3	1
LUAD	EPHX1 →	-1.071	-0.459	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,400 associations by consensus.

S1PR4 vs TFPT — LUAD

Explore this scatter interactively →