S1PR4

Across TCGA patient cohorts, S1PR4 protein abundance is significantly associated with the protein abundance of many other proteins, with 6,294 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible S1PR4-associated proteins across cancer lineages are RBBP8NL_S283, RBKS, and PBRM1_S1453. Each is linked with S1PR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both S1PR4-to-partner and partner-to-S1PR4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, S1PR4 versus RBBP8NL_S283 in LUAD, with a Pearson correlation of 0.74.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (S1PR4→partner) and Y-score (partner→S1PR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RBBP8NL_S283 →	+1.618	+0.867	.001	.005	3	1
LUAD	RBKS →	-0.357	-0.431	<.001	<.001	3	1
LUAD	PBRM1_S1453 →	+1.143	+0.356	<.001	<.001	3	1
LUAD	PEX3_S201 →	+2.098	+0.819	.002	<.001	3	1
LUAD	PHLDB1_S465 →	-0.664	-0.656	.001	.001	3	1
LUAD	PKN2_T124 →	+1.016	+0.424	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,294 associations by consensus.

S1PR4 vs RBBP8NL_S283 — LUAD

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