S1PR4

Across TCGA cell cohorts, S1PR4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,302 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible S1PR4-associated GO terms across cancer lineages are Positive regulation of protein localization to plasma membrane, Regulation of myoblast fusion, and Negative regulation of myoblast fusion. Each is linked with S1PR4 in more than 8 cancer types. Because this analysis shows association rather than direction, both S1PR4-to-partner and partner-to-S1PR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein localization to plasma membrane grouped by S1PR4-low versus S1PR4-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (S1PR4→partner) and Y-score (partner→S1PR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of protein localization to plasma membrane →	+0.070	+0.054	<.001	.002	3	9
URINARY_TRACT	Regulation of myoblast fusion →	+0.090	+0.265	<.001	.005	3	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.093	+0.315	.004	<.001	3	8
URINARY_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.090	+0.276	<.001	.004	2	9
URINARY_TRACT	Chemokine-mediated signaling pathway →	-0.112	-0.300	.001	.003	3	8
SKIN	Regulation of autophagy of mitochondrion →	+0.069	+0.246	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,302 associations by consensus.

Positive regulation of protein localization to plasma membrane by S1PR4 expression — LUNG_SCLC

Explore this box plot interactively →