Across TCGA pan-cancer cohorts, S1PR3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated S1PR3 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher S1PR3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated S1PR3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

GBM and LUAD are the cancer types where S1PR3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.236	0.440	.005	14	view →
LUAD	OS	Median	All	1.000	0.341	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: S1PR3 tumor-vs-normal RNA expression · all S1PR3 data types