Across TCGA patient cohorts, S1PR3 mutation is significantly associated with the RNA expression of many other genes, with 3,523 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible S1PR3-associated genes across cancer lineages are MIR6803, PLB1, and ATP5MG. Each is linked with S1PR3 in more than 2 cancer types. Because this analysis shows association rather than direction, both S1PR3-to-partner and partner-to-S1PR3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S1PR3→partner) and Y-score (partner→S1PR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6803 →	+0.481	+4.328	<.001	.007	3	3
UCEC	PLB1 →	-0.434	-3.885	.002	<.001	3	3
UCEC	ATP5MG →	+0.385	+3.031	<.001	<.001	3	3
UCEC	ESCO2 →	+0.720	+2.671	<.001	<.001	3	3
UCEC	NDUFA12 →	+0.257	+2.370	.007	.003	3	3
STAD	RNU7-24P →	+0.349	+3.187	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,523 associations by consensus.

Exploration

S1PR3 survival (RNA) · tumor vs normal (RNA) · all S1PR3 data types