Across TCGA patient cohorts, S1PR3 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible S1PR3-associated genes across cancer lineages are ATM, 4E-BP1, and MIG-6. Each is linked with S1PR3 in more than 2 cancer types. Because this analysis shows association rather than direction, both S1PR3-to-partner and partner-to-S1PR3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S1PR3→partner) and Y-score (partner→S1PR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.370	-1.765	.029	.014	3	3
UCEC	4E-BP1 →	+0.267	+3.351	.008	.005	3	3
COAD	MIG-6 →	+0.087	+2.334	.043	.018	3	2
UCEC	A-Raf_pS299 →	-0.103	-2.584	.022	.010	3	2
UCEC	mTOR_pS2448 →	-0.119	-2.095	.033	.017	3	2
UCEC	p62 Lck ligand →	+0.421	+2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

S1PR3 survival (RNA) · tumor vs normal (RNA) · all S1PR3 data types