Across TCGA cell cohorts, S1PR3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible S1PR3-associated genes across cancer lineages are POTED, CCDC172, and CXorf51A. Each is linked with S1PR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both S1PR3-to-partner and partner-to-S1PR3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S1PR3→partner) and Y-score (partner→S1PR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	POTED →	+1.065	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	CCDC172 →	+0.639	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	CXorf51A →	+0.153	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	USP17L11 →	+0.022	+4.867	<.001	.009	3	1
BLOOD_Leukemia	TEX43 →	+0.141	+5.969	<.001	.001	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.124	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

S1PR3 survival (RNA) · tumor vs normal (RNA) · all S1PR3 data types