S1PR2

Across TCGA pan-cancer cohorts, S1PR2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated S1PR2 data layer compared with 27 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher S1PR2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated S1PR2 expression acts as an unfavorable survival marker.

SKCM, PRAD, and DLBC are the cancer types where S1PR2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.218	0.624	<.001	21	view →
PRAD	DFS	Median	All	0.085	0.774	.007	6	view →
DLBC	OS	Median	All	0.613	0.945	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

S1PR2–SKCM (DFS)

Open the SKCM breakdown →