S1PR1

Across TCGA patient cohorts, S1PR1 mutation is significantly associated with the RNA expression of many other genes, with 3,704 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible S1PR1-associated genes across cancer lineages are COPS3, SFXN1, and SNRPD1. Each is linked with S1PR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both S1PR1-to-partner and partner-to-S1PR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPS3 grouped by S1PR1-low versus S1PR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S1PR1→partner) and Y-score (partner→S1PR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COPS3 →	+0.649	+2.643	<.001	<.001	3	4
UCEC	SFXN1 →	+0.532	+3.191	<.001	<.001	3	3
UCEC	SNRPD1 →	+0.505	+2.654	<.001	<.001	3	3
UCEC	TIPIN →	+0.508	+2.284	<.001	<.001	3	3
UCEC	UBE2K →	+0.333	+2.021	.006	.005	3	3
UCEC	CDC7 →	+0.666	+2.423	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,704 associations by consensus.

COPS3 by S1PR1 expression — UCEC

Explore this box plot interactively →