S1PR1

Across TCGA cell cohorts, S1PR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,541 significant associations in total. BONE shows the largest number of these associations.

The most reproducible S1PR1-associated GO terms across cancer lineages are Serotonin transport, Positive regulation of cytoskeleton organization, and Cellular response to molecule of fungal origin. Each is linked with S1PR1 in more than 9 cancer types. Because this analysis shows association rather than direction, both S1PR1-to-partner and partner-to-S1PR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Serotonin transport grouped by S1PR1-low versus S1PR1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (S1PR1→partner) and Y-score (partner→S1PR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Serotonin transport →	-1.552	-1.861	<.001	.004	3	10
LUNG_NSCLC_LUSC	Positive regulation of cytoskeleton organization →	+0.097	+2.094	<.001	.002	3	9
STOMACH	Cellular response to molecule of fungal origin →	-1.647	-0.953	<.001	.005	3	9
BONE	Positive regulation of cell-substrate junction organization →	+0.166	+1.573	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Peptidyl-lysine oxidation →	+1.693	+2.708	<.001	<.001	3	9
BONE	Positive regulation of early endosome to late endosome transport →	+0.132	+1.520	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,541 associations by consensus.

Serotonin transport by S1PR1 expression — URINARY_TRACT

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