S100PBP

Across TCGA patient cohorts, S100PBP mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible S100PBP-associated genes across cancer lineages are C-Raf, Ku80, and MAPK_pT202_Y204. Each is linked with S100PBP in more than 1 cancer types. Because this analysis shows association rather than direction, both S100PBP-to-partner and partner-to-S100PBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by S100PBP-low versus S100PBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S100PBP→partner) and Y-score (partner→S100PBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.150	+2.321	.037	.035	3	2
UCEC	Ku80 →	+0.257	+2.335	.030	.020	3	1
UCEC	MAPK_pT202_Y204 →	-0.520	-3.000	.027	.036	3	1
UCEC	p62 Lck ligand →	+0.334	+2.817	.041	.036	2	2
UCEC	PKC-b-II_pS660 →	-0.369	-3.169	.007	.019	3	1
UCEC	STAT3_pY705 →	-0.403	-2.321	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

C-Raf by S100PBP expression — UCEC

Explore this box plot interactively →