S100A9

Across TCGA pan-cancer cohorts, S100A9 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated S100A9 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher S100A9 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated S100A9 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and UCEC are the cancer types where S100A9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	II,III,IV	0.962	0.639	.003	33	view →
CCRCC	DFS	Quartile	All	1.000	0.830	.011	15	view →
UCEC	OS	Median	All	1.000	0.902	.006	10	view →
LUAD	OS	Median	II,III,IV	0.862	1.000	.004	8	view →
PDAC	OS	Tertile	II,III,IV	0.684	0.957	.012	8	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
GBM	OS	Tertile	All	0.404	0.685	.017	2	view →
LSCC	DFS	Median	All	0.828	0.498	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

S100A9–HNSC (OS)

Open the HNSC breakdown →