S100A8

Across TCGA pan-cancer cohorts, S100A8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated S100A8 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher S100A8 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated S100A8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where S100A8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.931	0.614	.002	27	view →
CCRCC	DFS	Tertile	All	1.000	0.862	.007	23	view →
PDAC	OS	Tertile	All	0.705	0.959	.013	7	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
LUAD	OS	Median	All	0.937	0.982	.012	3	view →
LSCC	DFS	Median	All	0.828	0.498	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

S100A8–HNSC (OS)

Open the HNSC breakdown →