S100A8

Across TCGA patient cohorts, S100A8 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,851 significant associations in total. GBM shows the largest number of these associations.

The most reproducible S100A8-associated proteins across cancer lineages are S100A12, S100A9, and ITGAM. Each is linked with S100A8 in more than 9 cancer types. Because this analysis shows association rather than direction, both S100A8-to-partner and partner-to-S100A8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, S100A8 versus S100A12 in GBM, with a Pearson correlation of 0.71.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (S100A8→partner) and Y-score (partner→S100A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	S100A12 →	+1.619	+1.830	<.001	<.001	3	10
BRCA	S100A9 →	+1.672	+3.478	<.001	<.001	3	10
PDAC	ITGAM →	+0.907	+1.382	<.001	<.001	3	9
GBM	MPO →	+1.300	+1.868	<.001	<.001	3	9
BRCA	S100A9_T113 →	+1.485	+3.040	<.001	<.001	3	9
GBM	BPI →	+1.491	+1.553	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,851 associations by consensus.

S100A8 vs S100A12 — GBM

Explore this scatter interactively →