S100A8

Across TCGA patient cohorts, S100A8 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible S100A8-associated genes across cancer lineages are MTND4LP12, KPNA2P1, and FCF1P3. Each is linked with S100A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both S100A8-to-partner and partner-to-S100A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND4LP12 grouped by S100A8-low versus S100A8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S100A8→partner) and Y-score (partner→S100A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTND4LP12 →	+0.070	+4.900	<.001	.002	3	1
SKCM	KPNA2P1 →	+0.118	+3.697	<.001	.007	3	1
SKCM	FCF1P3 →	+0.208	+2.885	<.001	.008	3	1
SKCM	ACTG1P13 →	+0.037	+3.186	<.001	.009	3	1
SKCM	RN7SL135P →	+0.063	+4.408	<.001	.005	3	1
SKCM	TRPC7-AS1 →	+0.135	+2.748	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

MTND4LP12 by S100A8 expression — SKCM

Explore this box plot interactively →