S100A8

Across TCGA cell cohorts, S100A8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,893 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible S100A8-associated GO terms across cancer lineages are Response to mycotoxin, Establishment of protein localization to endoplasmic reticulum, and Inner cell mass cell differentiation. Each is linked with S100A8 in more than 8 cancer types. Because this analysis shows association rather than direction, both S100A8-to-partner and partner-to-S100A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to mycotoxin grouped by S100A8-low versus S100A8-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (S100A8→partner) and Y-score (partner→S100A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Response to mycotoxin →	+1.028	+3.617	<.001	<.001	3	9
BREAST	Establishment of protein localization to endoplasmic reticulum →	+0.089	+3.987	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Inner cell mass cell differentiation →	+1.747	+5.452	<.001	<.001	3	8
URINARY_TRACT	Regulation of synapse structural plasticity →	-1.239	-2.660	<.001	.002	3	8
BLOOD_Leukemia	Antimicrobial peptide production →	+1.168	+2.865	<.001	<.001	3	7
BLOOD_Leukemia	Antimicrobial peptide biosynthetic process →	+1.168	+2.865	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,893 associations by consensus.

Response to mycotoxin by S100A8 expression — URINARY_TRACT

Explore this box plot interactively →