Across TCGA patient cohorts, S100A6 protein abundance is significantly associated with the RNA expression of many other genes, with 6,435 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible S100A6-associated genes across cancer lineages are AHNAK, S100A10, and S100A5. Each is linked with S100A6 in more than 5 cancer types. Because this analysis shows association rather than direction, both S100A6-to-partner and partner-to-S100A6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S100A6→partner) and Y-score (partner→S100A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AHNAK →	+0.641	+0.535	<.001	<.001	3	6
GBM	S100A10 →	+0.878	+0.563	.005	.003	3	6
OV	S100A5 →	+1.638	+1.220	<.001	<.001	3	6
UCEC	PTK6 →	+1.213	+0.701	<.001	.002	3	5
GBM	ABCC3 →	+1.503	+0.528	<.001	.001	3	5
UCEC	LIPH →	+1.230	+0.957	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,435 associations by consensus.

Exploration

S100A6 survival (RNA) · tumor vs normal (RNA) · all S100A6 data types