Across TCGA patient cohorts, S100A4 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,938 significant associations in total. GBM shows the largest number of these associations.

The most reproducible S100A4-associated proteins across cancer lineages are S100A2, C1S, and CALU. Each is linked with S100A4 in more than 5 cancer types. Because this analysis shows association rather than direction, both S100A4-to-partner and partner-to-S100A4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (S100A4→partner) and Y-score (partner→S100A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	S100A2 →	+1.573	+0.891	<.001	<.001	3	6
BRCA	C1S →	+0.480	+0.674	<.001	<.001	3	5
GBM	CALU →	+0.428	+0.917	<.001	<.001	3	5
BRCA	CNN2 →	+0.856	+1.101	<.001	<.001	3	5
GBM	AHNAK2 →	+0.696	+1.168	<.001	<.001	3	5
GBM	DPYD →	+1.045	+1.187	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,938 associations by consensus.

Exploration

S100A4 survival (RNA) · tumor vs normal (RNA) · all S100A4 data types