Across TCGA patient cohorts, S100A4 mutation is significantly associated with the RNA expression of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible S100A4-associated genes across cancer lineages are MIR1179, OR5AQ1P, and MIR380. Each is linked with S100A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both S100A4-to-partner and partner-to-S100A4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S100A4→partner) and Y-score (partner→S100A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR1179 →	+0.353	+7.954	<.001	.008	3	2
UCEC	OR5AQ1P →	+0.106	+3.198	<.001	.009	3	1
UCEC	MIR380 →	+0.333	+4.464	<.001	.005	3	1
UCEC	RNU6-249P →	+0.551	+3.525	<.001	.001	3	1
UCEC	RNU6-236P →	+0.841	+3.193	<.001	.004	3	1
UCEC	SNORD114-18 →	+0.572	+3.562	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

Exploration

S100A4 survival (RNA) · tumor vs normal (RNA) · all S100A4 data types