Across TCGA patient cohorts, S100A3 mutation is significantly associated with the RNA expression of many other genes, with 280 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible S100A3-associated genes across cancer lineages are OR10G9, POLR2C, and SLC7A6OS. Each is linked with S100A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both S100A3-to-partner and partner-to-S100A3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S100A3→partner) and Y-score (partner→S100A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR10G9 →	+0.039	+7.816	<.001	.008	3	1
UCEC	POLR2C →	+0.618	+3.332	.001	.005	3	1
UCEC	SLC7A6OS →	+0.547	+3.354	.001	.005	3	1
UCEC	CMC2 →	+0.530	+3.235	.001	.009	3	1
UCEC	KCTD9 →	+0.904	+3.332	<.001	.005	3	1
UCEC	GLO1 →	+0.672	+3.354	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 280 associations by consensus.

Exploration

S100A3 survival (RNA) · tumor vs normal (RNA) · all S100A3 data types