Across TCGA pan-cancer cohorts, S100A15A RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of S100A15A’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where S100A15A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types S100A15A is over-expressed in tumor.
LUSC and BRCA are the cancer types where S100A15A tumor–normal differential expression is most reproducible.