Across TCGA pan-cancer cohorts, S100A14 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated S100A14 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher S100A14 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated S100A14 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, UCEC, and HNSC are the cancer types where S100A14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	II,III,IV	0.706	0.406	.012	6	view →
UCEC	OS	Median	All	0.986	0.914	.045	2	view →
HNSC	OS	Tertile	II,III,IV	0.895	0.770	.041	2	view →
LSCC	DFS	Tertile	All	0.970	0.878	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: S100A14 tumor-vs-normal RNA expression · all S100A14 data types