S100A11

Across TCGA pan-cancer cohorts, S100A11 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of S100A11’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where S100A11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types S100A11 is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

COAD, KIRP, and THCA are the cancer types where S100A11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in S100A11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+2.432	<.001	12	view →
KIRP	All	IV	+2.622	<.001	11	view →
THCA	Male	III,IV	+1.820	<.001	11	view →
KIRC	All	IV	+1.041	<.001	10	view →
LUSC	All	III,IV	+1.471	<.001	7	view →
UCEC	All	All	+1.757	<.001	6	view →
KICH	All	II,III,IV	−1.261	<.001	6	view →
BRCA	All	III,IV	+1.234	<.001	6	view →
LUAD	Female	II,III,IV	+0.789	<.001	6	view →
CHOL	Female	All	+5.239	<.001	5	view →
READ	All	All	+1.833	<.001	5	view →
LIHC	All	II,III,IV	+1.472	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

S100A11–COAD

Open the COAD breakdown →