Across TCGA pan-cancer cohorts, S100A10 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated S100A10 data layer compared with 3 for mutation status and 5 for mass-spec protein.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher S100A10 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated S100A10 expression acts as an unfavorable survival marker, although some lineages such as ESCA and THYM show a favorable association.
HNSC, LIHC, and LUAD are the cancer types where S100A10 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.