Across TCGA patient cohorts, RYR3 protein abundance is significantly associated with the RNA expression of many other genes, with 824 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible RYR3-associated genes across cancer lineages are KHNYN, GID8, and PXMP4. Each is linked with RYR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RYR3-to-partner and partner-to-RYR3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYR3→partner) and Y-score (partner→RYR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	KHNYN →	-0.512	-0.578	<.001	.004	3	1
PDAC	GID8 →	-0.460	-0.535	.004	.009	3	1
PDAC	PXMP4 →	-0.402	-0.553	.003	.004	3	1
PDAC	MAGED2 →	-0.437	-0.561	.003	.001	3	1
PDAC	ISYNA1 →	+0.770	+0.507	.006	.008	3	1
PDAC	AVL9 →	-0.377	-0.396	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 824 associations by consensus.

Exploration

RYR3 survival (RNA) · tumor vs normal (RNA) · all RYR3 data types