Across TCGA patient cohorts, RYR3 mutation is significantly associated with the RNA expression of many other genes, with 11,469 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RYR3-associated genes across cancer lineages are NUSAP1, CDCA8, and KIF2C. Each is linked with RYR3 in more than 7 cancer types. Because this analysis shows association rather than direction, both RYR3-to-partner and partner-to-RYR3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYR3→partner) and Y-score (partner→RYR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	NUSAP1 →	+0.554	+3.956	<.001	<.001	3	8
LUAD	CDCA8 →	+0.553	+1.660	<.001	<.001	3	7
LUAD	KIF2C →	+0.767	+1.242	<.001	<.001	3	7
LUAD	CDCA5 →	+0.736	+1.230	<.001	<.001	3	7
UCEC	ZWILCH →	+0.339	+1.044	<.001	<.001	3	7
LUAD	MCM10 →	+0.655	+1.163	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,469 associations by consensus.

Exploration

RYR3 survival (RNA) · tumor vs normal (RNA) · all RYR3 data types