Across TCGA patient cohorts, RYR3 mutation is significantly associated with the total protein of many other genes, with 122 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible RYR3-associated genes across cancer lineages are mTOR_pS2448, Cyclin-E2, and Bak. Each is linked with RYR3 in more than 5 cancer types. Because this analysis shows association rather than direction, both RYR3-to-partner and partner-to-RYR3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYR3→partner) and Y-score (partner→RYR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	mTOR_pS2448 →	-0.146	-3.304	<.001	<.001	3	6
STAD	Cyclin-E2 →	+0.116	+1.342	.004	.016	3	6
CESC	Bak →	+0.115	+2.205	.044	.030	3	5
STAD	Rictor →	-0.738	-2.099	.015	.016	3	5
STAD	YAP_pS127 →	-0.241	-1.584	.014	.008	3	5
COAD	ASNS →	+0.368	+1.552	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 122 associations by consensus.

Exploration

RYR3 survival (RNA) · tumor vs normal (RNA) · all RYR3 data types