Across TCGA cell cohorts, RYR3 mutation is significantly associated with the RNA expression of many other genes, with 1,758 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RYR3-associated genes across cancer lineages are PIGT, SLC25A4, and MTERF3. Each is linked with RYR3 in more than 3 cancer types. Because this analysis shows association rather than direction, both RYR3-to-partner and partner-to-RYR3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYR3→partner) and Y-score (partner→RYR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PIGT →	-0.634	-2.539	<.001	<.001	3	4
LARGE_INTESTINE	SLC25A4 →	+0.598	+2.700	<.001	<.001	3	4
LARGE_INTESTINE	MTERF3 →	+0.451	+1.364	.003	.002	3	4
LARGE_INTESTINE	MARCHF5 →	+0.505	+1.807	.001	.005	3	4
LUNG_SCLC	OTUD6B →	+0.748	+2.807	<.001	<.001	3	3
LARGE_INTESTINE	NUP88 →	+0.512	+1.782	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,758 associations by consensus.

Exploration

RYR3 survival (RNA) · tumor vs normal (RNA) · all RYR3 data types