Across TCGA patient cohorts, RYR2 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,829 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RYR2-associated proteins across cancer lineages are SYNPO, CNRIP1, and EEA1. Each is linked with RYR2 in more than 7 cancer types. Because this analysis shows association rather than direction, both RYR2-to-partner and partner-to-RYR2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RYR2→partner) and Y-score (partner→RYR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYNPO →	+0.477	+0.579	.001	.001	3	8
GBM	CNRIP1 →	+0.803	+1.946	<.001	<.001	3	7
UCEC	EEA1 →	+0.348	+0.990	<.001	<.001	3	7
BRCA	AKAP12_S612 →	+0.854	+0.379	.001	.007	3	7
BRCA	TLN2 →	+0.575	+0.257	<.001	.009	3	6
GBM	AKAP12_T1116 →	+0.861	+1.487	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,829 associations by consensus.

Exploration

RYR2 survival (RNA) · tumor vs normal (RNA) · all RYR2 data types