Across TCGA patient cohorts, RYR2 protein abundance is significantly associated with the RNA expression of many other genes, with 3,356 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RYR2-associated genes across cancer lineages are PRODH, GRK3, and PIK3IP1. Each is linked with RYR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RYR2-to-partner and partner-to-RYR2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYR2→partner) and Y-score (partner→RYR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+1.206	+0.611	<.001	<.001	3	1
GBM	GRK3 →	+0.387	+0.522	.003	<.001	3	1
GBM	PIK3IP1 →	+0.471	+0.345	.002	.003	3	1
GBM	SOX10 →	+1.328	+0.680	<.001	<.001	3	1
GBM	SLC16A8 →	+0.703	+0.599	<.001	<.001	3	1
GBM	SEPTIN3 →	+1.440	+0.668	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,356 associations by consensus.

Exploration

RYR2 survival (RNA) · tumor vs normal (RNA) · all RYR2 data types