Across TCGA cell cohorts, RYR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,445 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RYR2-associated GO terms across cancer lineages are Left ventricular cardiac muscle tissue morphogenesis, Cardiac left ventricle morphogenesis, and Positive regulation of the force of heart contraction. Each is linked with RYR2 in more than 11 cancer types. Because this analysis shows association rather than direction, both RYR2-to-partner and partner-to-RYR2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RYR2→partner) and Y-score (partner→RYR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Left ventricular cardiac muscle tissue morphogenesis →	-0.380	-0.821	<.001	.007	2	12
BLOOD_Leukemia	Cardiac left ventricle morphogenesis →	-0.215	-0.927	<.001	.001	3	8
PANCREAS	Positive regulation of the force of heart contraction →	-0.936	-0.801	<.001	<.001	3	7
BREAST	Electron transport chain →	+0.054	+0.506	.002	.005	3	7
SOFT_TISSUE	Cytoplasmic translation →	+0.064	+0.441	<.001	.002	3	7
SOFT_TISSUE	Ventricular cardiac muscle tissue development →	-0.086	-0.448	.003	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,445 associations by consensus.

Exploration

RYR2 survival (RNA) · tumor vs normal (RNA) · all RYR2 data types