Across TCGA cell cohorts, RYR2 mutation is significantly associated with the RNA expression of many other genes, with 1,915 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RYR2-associated genes across cancer lineages are CCDC163, PRR14L, and CCDC116. Each is linked with RYR2 in more than 4 cancer types. Because this analysis shows association rather than direction, both RYR2-to-partner and partner-to-RYR2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYR2→partner) and Y-score (partner→RYR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC163 →	+0.578	+2.222	<.001	<.001	3	5
LARGE_INTESTINE	PRR14L →	+0.569	+1.686	<.001	<.001	3	4
STOMACH	CCDC116 →	+0.246	+3.378	<.001	<.001	3	4
OVARY	B3GNT4 →	+0.836	+3.584	<.001	<.001	3	4
LARGE_INTESTINE	NUDT5 →	+0.362	+1.389	.004	.006	3	4
LARGE_INTESTINE	SARS1 →	+0.702	+1.458	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,915 associations by consensus.

Exploration

RYR2 survival (RNA) · tumor vs normal (RNA) · all RYR2 data types