Across TCGA patient cohorts, RYR1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,367 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible RYR1-associated genes across cancer lineages are C12orf56, SLCO1A2, and RBAK. Each is linked with RYR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RYR1-to-partner and partner-to-RYR1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYR1→partner) and Y-score (partner→RYR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C12orf56 →	-0.936	-0.620	.001	.002	3	2
HNSC	SLCO1A2 →	-1.457	-1.331	<.001	<.001	3	2
LSCC	RBAK →	-0.387	-0.376	.002	.001	3	2
LSCC	AFF2 →	-0.927	-0.366	.003	.002	3	2
LSCC	ERC2 →	-0.950	-0.344	<.001	.002	3	2
HNSC	SYCP2 →	-1.192	-0.574	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,367 associations by consensus.

Exploration

RYR1 survival (RNA) · tumor vs normal (RNA) · all RYR1 data types