Across TCGA patient cohorts, RYR1 mutation is significantly associated with the total protein of many other genes, with 107 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RYR1-associated genes across cancer lineages are Caspase-7-cleavedD198, MYH11, and PCNA. Each is linked with RYR1 in more than 6 cancer types. Because this analysis shows association rather than direction, both RYR1-to-partner and partner-to-RYR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYR1→partner) and Y-score (partner→RYR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.823	+1.717	<.001	<.001	3	7
STAD	MYH11 →	-1.450	-1.584	<.001	<.001	3	5
STAD	PCNA →	+0.181	+1.662	.016	.007	3	5
STAD	Caveolin-1 →	-0.807	-1.784	<.001	<.001	3	5
SKCM	c-Kit →	-0.341	-1.146	.012	.005	3	5
UCEC	eEF2 →	+0.200	+1.169	.008	.012	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

Exploration

RYR1 survival (RNA) · tumor vs normal (RNA) · all RYR1 data types