Across TCGA cell cohorts, RYR1 RNA expression is significantly associated with the RNA expression of many other genes, with 7,657 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible RYR1-associated genes across cancer lineages are HEYL, ITGA2B, and ZYG11A. Each is linked with RYR1 in more than 7 cancer types. Because this analysis shows association rather than direction, both RYR1-to-partner and partner-to-RYR1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYR1→partner) and Y-score (partner→RYR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	HEYL →	+2.432	+2.745	<.001	<.001	3	8
OESOPHAGUS	ITGA2B →	+1.508	+2.712	.001	.003	3	7
OESOPHAGUS	ZYG11A →	+1.776	+3.234	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	FOXO6 →	+1.213	+2.099	.005	.001	3	5
OESOPHAGUS	TINCR →	+2.368	+3.043	<.001	<.001	3	5
BREAST	C1GALT1C1L →	+0.900	+1.587	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,657 associations by consensus.

Exploration

RYR1 survival (RNA) · tumor vs normal (RNA) · all RYR1 data types