Across TCGA cell cohorts, RYR1 mutation is significantly associated with the RNA expression of many other genes, with 2,037 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RYR1-associated genes across cancer lineages are ZMYND8, PIGL, and FCHO1. Each is linked with RYR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RYR1-to-partner and partner-to-RYR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYR1→partner) and Y-score (partner→RYR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZMYND8 →	-0.718	-1.847	<.001	<.001	3	4
LARGE_INTESTINE	PIGL →	+0.714	+3.700	<.001	<.001	3	3
LUNG_NSCLC_LUAD	FCHO1 →	+1.218	+2.428	<.001	<.001	3	3
OVARY	LMO7 →	-1.331	-2.459	.002	.009	3	3
OVARY	SSMEM1 →	+0.032	+2.095	.003	.006	3	3
OVARY	ZNF286B →	+0.745	+2.399	.007	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,037 associations by consensus.

Exploration

RYR1 survival (RNA) · tumor vs normal (RNA) · all RYR1 data types