RYBP

Across TCGA patient cohorts, RYBP mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RYBP-associated genes across cancer lineages are mTOR_pS2448, ASNS, and EGFR_pY1068. Each is linked with RYBP in more than 1 cancer types. Because this analysis shows association rather than direction, both RYBP-to-partner and partner-to-RYBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by RYBP-low versus RYBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYBP→partner) and Y-score (partner→RYBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.156	-3.156	.011	.018	3	2
UCEC	ASNS →	+0.563	+2.115	<.001	.017	3	2
UCEC	EGFR_pY1068 →	-0.239	-2.321	.021	.006	3	1
UCEC	eIF4E →	+0.187	+3.584	.032	.002	3	1
UCEC	A-Raf_pS299 →	-0.120	-2.115	.015	.017	3	1
UCEC	ACC1 →	+0.321	+3.013	.032	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

mTOR_pS2448 by RYBP expression — UCEC

Explore this box plot interactively →