RYBP

Across TCGA cell cohorts, RYBP mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. CNS shows the largest number of these associations.

The most reproducible RYBP-associated genes across cancer lineages are GK2, LRIT1, and IL25. Each is linked with RYBP in more than 1 cancer types. Because this analysis shows association rather than direction, both RYBP-to-partner and partner-to-RYBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GK2 grouped by RYBP-low versus RYBP-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYBP→partner) and Y-score (partner→RYBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GK2 →	+0.007	+4.169	<.001	.008	3	2
BONE	LRIT1 →	+0.163	+5.169	<.001	.004	3	1
BONE	IL25 →	+0.066	+5.169	<.001	.004	3	1
BONE	OR2T2 →	+0.036	+5.169	<.001	.004	3	1
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1
BLOOD_Leukemia	OR10V1 →	+0.046	+6.569	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GK2 by RYBP expression — CNS

Explore this box plot interactively →