RXYLT1

Across TCGA patient cohorts, RXYLT1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RXYLT1-associated genes across cancer lineages are TIGAR, EGFR_pY1068, and ACC1. Each is linked with RXYLT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RXYLT1-to-partner and partner-to-RXYLT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by RXYLT1-low versus RXYLT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXYLT1→partner) and Y-score (partner→RXYLT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.212	+2.114	<.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.202	-2.087	.035	.005	3	1
UCEC	ACC1 →	+0.348	+3.013	.012	.018	3	1
UCEC	MEK1 →	+0.282	+2.321	.044	.034	3	1
UCEC	Notch1 →	+0.121	+2.183	.024	.033	3	1
UCEC	p62 Lck ligand →	+0.251	+1.710	.044	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

TIGAR by RXYLT1 expression — UCEC

Explore this box plot interactively →