RXYLT1

Across TCGA cell cohorts, RXYLT1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible RXYLT1-associated genes across cancer lineages are GFRA4, DEFB124, and SCGB1C1. Each is linked with RXYLT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RXYLT1-to-partner and partner-to-RXYLT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by RXYLT1-low versus RXYLT1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXYLT1→partner) and Y-score (partner→RXYLT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GFRA4 →	+0.020	+4.584	<.001	.001	3	1
LUNG_NSCLC_LUSC	DEFB124 →	+0.187	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUSC	SCGB1C1 →	+0.088	+4.108	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GFRA4 by RXYLT1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →