RXRG

Across TCGA patient cohorts, RXRG mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RXRG-associated genes across cancer lineages are c-Jun_pS73, PCNA, and INPP4B. Each is linked with RXRG in more than 2 cancer types. Because this analysis shows association rather than direction, both RXRG-to-partner and partner-to-RXRG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Jun_pS73 grouped by RXRG-low versus RXRG-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXRG→partner) and Y-score (partner→RXRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	c-Jun_pS73 →	-0.165	-3.321	.040	.010	3	3
LUAD	PCNA →	+0.260	+3.321	.002	.010	2	3
UCEC	INPP4B →	-0.316	-2.584	.010	.010	3	2
COAD	MIG-6 →	+0.142	+2.820	.003	.035	3	2
UCEC	PAI-1 →	+0.422	+2.807	.001	.003	3	2
UCEC	Src_pY527 →	-0.381	-2.321	.021	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

c-Jun_pS73 by RXRG expression — LUAD

Explore this box plot interactively →