RXRG

Across TCGA cell cohorts, RXRG mutation is significantly associated with the RNA expression of many other genes, with 232 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RXRG-associated genes across cancer lineages are FTMT, C3orf22, and OFCC1. Each is linked with RXRG in more than 1 cancer types. Because this analysis shows association rather than direction, both RXRG-to-partner and partner-to-RXRG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTMT grouped by RXRG-low versus RXRG-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXRG→partner) and Y-score (partner→RXRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FTMT →	+0.086	+5.977	<.001	.001	3	2
LARGE_INTESTINE	C3orf22 →	+0.055	+3.029	<.001	.001	3	2
LARGE_INTESTINE	OFCC1 →	+0.455	+3.041	<.001	.001	3	2
BLOOD_Leukemia	OR11H12 →	+0.204	+4.551	<.001	.004	3	2
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	1
PANCREAS	UNC45B →	+0.006	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 232 associations by consensus.

FTMT by RXRG expression — SOFT_TISSUE

Explore this box plot interactively →