Across TCGA patient cohorts, RXRB mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RXRB-associated genes across cancer lineages are ATM, EGFR_pY1068, and eIF4E. Each is linked with RXRB in more than 2 cancer types. Because this analysis shows association rather than direction, both RXRB-to-partner and partner-to-RXRB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXRB→partner) and Y-score (partner→RXRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.562	-2.321	.002	.006	3	3
UCEC	EGFR_pY1068 →	-0.224	-1.807	.030	.027	3	1
UCEC	eIF4E →	+0.217	+3.013	.012	.018	3	1
UCEC	Ku80 →	+0.228	+1.884	.019	.030	3	1
UCEC	mTOR_pS2448 →	-0.183	-2.565	.003	.010	3	1
UCEC	Notch1 →	+0.184	+3.331	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

RXRB survival (RNA) · tumor vs normal (RNA) · all RXRB data types