RXRA

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RXRA mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RXRA-associated genes across cancer lineages are FASN, ATM, and MEK1. Each is linked with RXRA in more than 2 cancer types. Because this analysis shows association rather than direction, both RXRA-to-partner and partner-to-RXRA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXRA→partner) and Y-score (partner→RXRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BLCAFASN →+0.413+1.906.030.01633
COADATM →-0.635-3.000<.001.03433
UCECMEK1 →+0.300+1.584.023.03433
UCECBak →+0.231+2.459.010.01832
COADEGFR_pY1068 →-0.321-3.161.047.01932
UCECeIF4E →+0.156+1.750.040.04932
Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Exploration