RXFP3

Across TCGA patient cohorts, RXFP3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RXFP3-associated genes across cancer lineages are FOXO3a_pS318_S321, GAPDH, and PCNA. Each is linked with RXFP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RXFP3-to-partner and partner-to-RXFP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by RXFP3-low versus RXFP3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXFP3→partner) and Y-score (partner→RXFP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FOXO3a_pS318_S321 →	-0.199	-2.000	.002	.028	3	3
STAD	GAPDH →	+0.268	+2.000	.027	.028	3	3
STAD	PCNA →	+0.283	+3.584	.005	.002	3	3
UCEC	4E-BP1 →	+0.309	+2.444	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.490	+1.678	.004	.019	3	3
COAD	PR →	-0.177	-2.309	.031	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

FOXO3a_pS318_S321 by RXFP3 expression — STAD

Explore this box plot interactively →