RXFP3

Across TCGA cell cohorts, RXFP3 mutation is significantly associated with the RNA expression of many other genes, with 310 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RXFP3-associated genes across cancer lineages are TSHB, BTNL2, and CCT8. Each is linked with RXFP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RXFP3-to-partner and partner-to-RXFP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSHB grouped by RXFP3-low versus RXFP3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXFP3→partner) and Y-score (partner→RXFP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TSHB →	+0.056	+3.604	<.001	.004	3	2
OVARY	BTNL2 →	+0.092	+2.974	.001	.006	3	2
LARGE_INTESTINE	CCT8 →	+0.565	+3.321	<.001	.002	3	2
LARGE_INTESTINE	ESF1 →	+0.462	+3.067	.003	.009	3	2
LUNG_NSCLC_LUAD	ODF1 →	+0.057	+4.415	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR51B4 →	+0.804	+3.614	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 310 associations by consensus.

TSHB by RXFP3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →