RXFP1

Across TCGA patient cohorts, RXFP1 mutation is significantly associated with the RNA expression of many other genes, with 4,818 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RXFP1-associated genes across cancer lineages are HMGB1P50, SSRP1, and CHEK1. Each is linked with RXFP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RXFP1-to-partner and partner-to-RXFP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P50 grouped by RXFP1-low versus RXFP1-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXFP1→partner) and Y-score (partner→RXFP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	HMGB1P50 →	+0.093	+3.906	<.001	.006	3	3
LUAD	SSRP1 →	+0.499	+3.375	.002	.004	3	3
UCEC	CHEK1 →	+0.624	+1.523	<.001	<.001	3	3
SKCM	KIN →	+0.449	+2.427	.001	.001	3	3
UCEC	EME1 →	+0.492	+1.680	<.001	<.001	3	3
UCEC	SASS6 →	+0.435	+2.075	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,818 associations by consensus.

HMGB1P50 by RXFP1 expression — LGG

Explore this box plot interactively →